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Mary Ann Liebert | English | 2010 | ISBN-10: 1934854166 | 350 pages | PDF | 437.62 mb
by Peter C. Johnson (Author, Editor), MD (Author, Editor), Antonios G. Mikos (Author, Editor), PhD (Author, Editor)
Angiogenic control has proven to be one of the most difficult aspects of tissue engineering to master. This presents broad-based anatomic and physiologic challenges to the tissue engineer. Key controllers of angiogenesis have been formed to be mechanical forces, small molecules (drugs and growth factors), co-culture with non-vascular cells, biomaterials, and stem cells. This volume addresses vascular assembly techniques and the transplantation of microvascular networks. Advances in Tissue Engineering, Volume 1: Angiogenesis presents leading-edge research and insight on: The mechanisms of angiogenesis, as studied in developmental biology models The application of systems biology to help us understand how choke points might be controlled by drugs or other approaches The physiological functioning of engineered capillaries, venules, and arterioles Creation of networks that have large enough arterial and venous components to enable direct anastomosis to host vessels Vascular assembly techniques and transplantation of microvascular networks
Vascular growth and stem cells undoubtedly play a central role in normal tissue development and growth. The grand challenge is to figure out how to transform the ever-expanding knowledge of key biomolecular signals that regulate tissue morphogenesis into therapies that promote functional tissue regeneration. The Advances in Tissue Engineering book series begins with a state-of-the-art collection of the latest scientific advances in therapeutic angiogenesis and stem cell delivery strategies that will be needed to enable development of the next generation of tissue regenerative technologies. ––Robert Guldberg, PhD Georgia Institute of Technology The George W. Woodruff School of Mechanical Engineering
The Advances in Tissue Engineering book series is an important new tool to students, scientists, and engineers interested in the field of tissue engineering and regenerative medicine. It identifies the important issues of the field and provides the reader with state-of-the-art knowledge which can then be applied to new solutions. –Joseph. P. Vacanti, MD Harvard Stem Cell Institute Massachusetts General Hospital